APC Anti-Mouse CD357 (AITR / GITR) (DTA-1)

TDS | SDS The DTA-1 antibody reacts with mouse CD357, also known as GITR or AITR (in humans), a 66-70 kDa member of the Tumor Necrosis Factor superfamily (TNFRSF18). GITR is primarily found on T cells, and its function may vary depending on the T cell type where it is expressed. GITR is upregulated on activated T cells where it provides co-stimulation, yet GITR may promote the inhibition of CD4+ CD25+ Treg cells, where it is expressed at high levels. GITR ligand (GITRL) is found on B cells, macrophages, dendritic and endothelial cells, and is implicated in regulating both innate and adaptive immune responses. The DTA-1 antibody may be used for analysis of GITR expression on T cells, and is also commonly used in vitro as an agonistic antibody to induce GITR signaling in various assays (use format appropriate for functional assays). Name APC Anti-Mouse CD357 (GITR) (DTA-1) Cat. No. 20-5874 Alternative Names TNFRSF18 Gene ID 21936 Clone DTA-1 Isotype Rat IgG2b Reactivity Mouse Format APC Application Flow Cytometry decorateTable('product-attribute-specs-table')