(KO Validated) MTA2 Polyclonal Antibody - E-AB-67426

(KO Validated) MTA2 Polyclonal Antibody Sizes: 60μL, 120μL, 200μL Catalogue Numbers: E-AB-67426-60, E-AB-67426-120, E-AB-67426-200 Citations, Manuals and MSDS Available upon request. Abbreviation: MTA2 Target Synonym: MTA2; MTA1L1; PID Research Areas: Cancer, Epigenetics and Nuclear Signaling Conjugation: Unconjugated Host: Rabbit Species Reactivity: Human, Mouse, Rat Application: WB Isotype: IgG Clonality: Polyclonal UNIProt ID: O94776 Background: This gene encodes a protein that has been identified as a component of NuRD, a nucleosome remodeling deacetylase complex identified in the nucleus of human cells. It shows a very broad expression pattern and is strongly expressed in many tissues. It may represent one member of a small gene family that encode different but related proteins involved either directly or indirectly in transcriptional regulation. Their indirect effects on transcriptional regulation may include chromatin remodeling. It is closely related to another member of this family, a protein that has been correlated with the metastatic potential of certain carcinomas. These two proteins are so closely related that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. One of the proteins known to be a target protein for this gene product is p53. Deacetylation of p53 is correlated with a loss of growth inhibition in transformed cells supporting a connection between these gene family members and metastasis. Concentration: 1mg/mL Immunogen: Recombinant fusion protein of human MTA2 (NP_004730.2). Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. Purification Method: Affinity purification Dilution: WB 1:500-1:2000 Calculated MW: 55kDa/75kDa Observed MW: 72kDa Storage: -20°C/One year. Avoid freeze / thaw cycles. Shipping: Ice bag Research Use Only