PS-341 (Bortezomib)

Catalog#: C-1279 Targets: Proteasome Synonym: PS-341; PS 341; PS341; LDP 341; LDP-341 ;LDP341; MLN341; MLN-341; MLN 341; VELCADE. Chemical Name/IUPAC:((R)-3-methyl-1-((S)-3-phenyl-2-(pyrazine-2-carboxamido)propanamido)butyl)boronic acid Technical Data Product Name: PS-341 (Bortezomib) Chemical Formula: C19H25BN4O4 Molecular Weight: 384.24 CAS#: 179324-69-7 Appearance: Solid powder Purity: > 99% by HPLC Solubility: Soluble in DMSO Storage: Room temperature for months, or -20ºC for 3 years Description PS-341 (Bortezomib) is a potent inhibitor of proteasome, and PS-341 reversibly inhibits the 26S proteasome, a large protease complex that degrades ubiquinated proteins. By blocking the targeted proteolysis normally performed by the proteasome, PS-341 disrupts various cell signaling pathways, leading to cell cycle arrest, apoptosis, and inhibition of angiogenesis.