EPZ-5676 (Pinometostat)

Catalog#: C-1133 Quantity: 5mg Targets: Histone Methyltransferase Synonym: EPZ5676; EPZ-5676; EPZ 5676; Pinometostat Chemical Name/IUPAC:(2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-((((1r,3S)-3-(2-(5-(tert-butyl)-1H-benzo[d]imidazol-2-yl)ethyl)cyclobutyl)(isopropyl)amino)methyl)tetrahydrofuran-3,4-diol Technical Data Product Name: EPZ-5676 (Pinometostat) Chemical Formula: C30H42N8O3 Molecular Weight: 562.7 CAS#: 1380288-87-8 Appearance: Solid powder Purity: > 99% by HPLC Solubility: Soluble in DMSO Storage: Room temperature for months, or -20ºC for 3 years Description EPZ-5676 (Pinometostat) is a small molecule inhibitor of histone methyltransferase with potential antineoplastic activity. Upon intravenous administration, EPZ-5676 specifically blocks the activity of the histone lysine-methyltransferase DOT1L, thereby inhibiting the methylation of nucleosomal histone H3 on lysine 79 (H3K79) that is bound to the mixed lineage leukemia (MLL) fusion protein which targets genes and blocks