ABT-737

C-1010 Targets: PARP Synonym: ABT 737; ABT-737; ABT737 Chemical Name/IUPAC:(R)-4-(4-((4'-chloro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)-N-((4-((4-(dimethylamino)-1-(phenylthio)butan-2-yl)amino)-3-nitrophenyl)sulfonyl)benzamide Technical Data Product Name: ABT-737 Chemical Formula: C42H45ClN6O5S2 Molecular Weight: 813.43 CAS#: 852808-04-9 Appearance: Solid powder Purity: > 99% by HPLC Solubility: Soluble in DMSO Storage: Room temperature for six months, or -20oC for three years DescriptionABT-737 is a BH3 mimetic inhibitor of Bcl-xL, Bcl-2 and Bcl-w with EC50 of 78.7 nM, 30.3 nM and 197.8 nM, respectively. ABT-737 has no inhibition observed against Mcl-1, Bcl-B or Bfl-1.