ABT-199 (Venectoclax)

C-1008 Targets: BCL-2 Synonym: ABT199; ABT-199; ABT 199; GDC0199; GDC0199; GDC 0199; RG7601; RG7601; RG 7601; Venetoclax Chemical Name/IUPAC:4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({3-nitro-4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide Technical Data Product Name: ABT-199 (Venectoclax) Chemical Formula: C45H50ClN7O7S Molecular Weight: 868.44 CAS#: 1257044-40-8 Appearance: Solid powder Purity: > 99% by HPLCLaboratory Supplies Solubility: Soluble in DMSO Storage: Room temperature for months, or -20ºC for Three years DescriptionABT-199 (venetoclax) is an orally bioavailable and selective small-molecule inhibitor of the anti-apoptotic protein BCL-2 with potential antineoplastic activity. ABT-199 mimics BH3-only proteins, the native ligands of Bcl-2 and apoptosis activators, by binding to the hydrophobic groove of BCL-2 proteins, thereby repressing BCL-2 activity and restoring apo