LeuSynergy™ 120 capsules nuBioAge

An exercise and caloric restriction mimetic that improvesSirtuin and NAD+ functions. This low-dose leucinecompound is best known for its incredible enhancementof weight loss with GLP 1’s like semaglutide. LeuSynergy + GLP-1s has become afoundational protocol for weight lossand metabolism optimization. Cellular PathwaysDelivering the right dose of Leucine decreases the amountof NAD needed to activate SIRT-1. * Leucine at a concentration of 0.5mM was shown to decrease the kM of NAD by 50% With Leucine, LESS NAD+ is needed for SIRT-1 functions, improving NAD+ utilization in other cellular pathways. Why this matters: SIRT-1 Downstream EffectsStimulates caloric restriction and exercise pathways through these gene transcription factors::PGC-1a: The core regulator of mitochondrial biogenesis, PPAR: Regulate fat oxidation, AMPK: Master regulator of cell energy, NF-kB: Inhibition leads to decreased inflammation and oxidative stress  Clinical Studies Leucine-Resveratrol Synergy Human Pre-diabetic Subjects Randomized: Leucine 1.1 g + Resveratrol 50mg Twice Daily vs. Placebo •     OGTT and 60 min glucose and insulin concentration•    Reduced insulin resistance by 33%•    Significant improvement and insulin/glucose dynamics Weight Loss – Fat Oxidation – Insulin Sensitivity Synergy with GLP-1s: Semaglutide, Tirzepatide, Liraglutide Studies show 15% reduction in body weight when semaglutide was accompanied by caloric restriction and exercise. Using an exercise mimetic like LeuSynergy is foundational in weight loss and metabolic health outcomes.  Insulin Independent Pathways for Glucose DisposalGLP-1: Increase in GLUT4 expression by activating AMPKLeuSynergy: Increase in GLUT4 expression through SIRT1  deacetylation of PGC-1a Improved Fat OxidationGLP-1: Direct effects on  hepatocytes by activating genes involved in beta-oxidation of fatty acidsLeuSynergy: Activation of PGC-1a and PPAR resulting in an increase in fatty acid oxidation and oxidative phosphorylation Oxidative Stress and Pancreatic  Beta Cell ProtectionGLP-1: Reduced oxidative stress in pancreatic islets. Increases B-cell mass by regulating cell kinectics and suppressing  oxidative and ER stress, and amerlioration of glucolipotoxicity.LeuSynergy: SIRT1 deacetylation and inhibition of NF-kB protecting beta cells from oxidative stress and inflammatory cytokines.  Ingredients • Leucine 1.1 grams• Resveratrol 50mg• Pyroxdine 15mg Recommended Use Take 2 tablets in the morning and 2 tablets 90 minutes after lunch.