Human Glycoprotein IIb/IIIa Purified
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Human Glycoprotein IIb/IIIa Purified

$470.00
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Human Glycoprotein IIb/IIIa Purified from Innovative Research has been purified from Human Platelets. This is a frozen liquid buffered in 20 mM Tris-HCl/0.1 M NaCl/1 mM CaCl2/0.05% NaN3/50% glycerol/ pH 7.4,. As observed on gels, GPIIb migrates as 136,000 (non-reduced) and 125,000 (reduced), and GPIIIa as 97,000 (non-reduced) and 108,000 (reduced). Glycoprotein IIb/IIIa is an integrin complex found on platelets that aids in platelet activation by functioning as a receptor for both Factor I (Fibrinogen) and von Willebrand Factor. The Glycoprotein IIb/IIIa complex is formed by calcium-dependent association of Glycoprotein IIb and Glycoprotien IIIa. This complex binds Factor I (Fibrinogen) to platelets, allowing multiple platelets to join together as they attach to the same strands of fibrinogen and form a clot. The coagulation cascade then continues, stabilizing the clot as Factor IIa (Thrombin) converts the soluble fibrinogen into insoluble fibrin strands that are then linked together b

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