cFluor® B548 Anti-Human CD8 (SK1)

The SK1 monoclonal antibody binds to human CD8a, a 32-34-kDa type I glycoprotein that forms either as an α/α homodimer α/β heterodimer with its isoform CD8b. CD8 is found on thymocytes, a subset of peripheral blood T cells, majority expressing α/β heterodimer, and NK cells, majority expressing α/α homodimer (1). CD8 plays a role in antigen recognition and class I MHC-restricted T cell development. CD8 functions are associated with two domains of CD8a. CD8a ectodomain binding to the α3 domain of MHC class I increases the adhesion between CD8+ T lymphocytes and target cells. The cytoplasmic tail binding to the tyrosine kinase p56lck contributes to signal transduction and T cell activation A (2)(3). The antibody was conjugated to a fluorophore and purified by affinity chromatography. PRODUCT DETAILS Clone:                  SK1 Reactivity:          Human, African Green, Chimpanzee, Cynomolgus, Pigtailed Macaque, Rhesus, Sooty Mangabey Format:              cFluor® B548* Isotype: