APC Anti-Human CD154 (CD40L) (5C8)

TDS | SDS The 5C8 antibody reacts with human CD154 which is also known as CD40L (CD40 ligand). CD154 is a 39kDa member of the TNF-α superfamily and is predominantly expressed on activated T cells but is also expressed on NK cells, mast cells, basophils, and eosinophils. CD154 binds to CD40, a molecule that is expressed on antigen presenting cells including B cells, monocytes/macrophages, and dendritic cells. The interaction of CD154 and CD40 regulates the activation of antigen presenting cells and is critical for B cell costimulation. The 5C8 antibody has been reported to block CD40L-CD40 interactions. Name APC Anti-Human CD154 (CD40L) (5C8) Cat. No. 20-1547 Alternative Names CD40L, gp39, T-BAM, TRAP, Ly-62 Gene ID 959 Clone 5C8 Isotype Mouse IgG2a, κ Reactivity Human Cross Reactivity rhesus monkey, cynomolgus monkey Format APC Application Flow Cytometry //