Alexa Fluor® 488 anti-human CD8

CD8a is a 32-34 kD type I glycoprotein. It forms a homodimer (CD8a/a) or heterodimer (CD8a/b) with CD8b. CD8, also known as T8 and Leu2, is a member of the immunoglobulin superfamily found on the majority of thymocytes, a subset of peripheral blood T cells, and NK cells (which express almost exclusively CD8a homodimers). CD8 acts as a co-receptor with MHC class I-restricted T cell receptors in antigen recognition and T cell activation and has been shown to play a role in thymic differentiation. Two domains in CD8a are important for function: the extracellular IgSF domain binds the α3 domain of MHC class I and the cytoplasmic CXCP motif binds the tyrosine kinase p56 Lck.PRODUCT DETAILSClone: SK1Antibody Type: MonoclonalReactivity: Human, Cynomolgus, RhesusFormat: Alexa Fluor 488Host: MouseIsotype: IgG1, κApplications: FC - Quality tested SB - Reported in the literature, not verified in houseRegulatory Status: RUOData Sheets: TDS | SDSNote to Purchaser: This product is manufactured and s