PNC-27

Primary Function: Targeted cancer cell apoptosis, p53 pathway activation Research Use: Tumor-targeted peptide therapy, p53-reactivation studies, selective apoptosis in cancer cells Molecular Formula: C70H110N18O16 CAS Number: N/A (custom-sequenced research peptide) Synonyms: p53-derived peptide, PNC27, tumor-targeting peptide Description: PNC-27 is a synthetic peptide derived from the tumor suppressor protein p53, designed to selectively induce apoptosis in cancer cells while leaving healthy cells unharmed. Its primary mechanism of action involves targeting and binding to HDM-2 (human double minute-2), a key regulator that inhibits p53 in many cancers. By reactivating the intrinsic apoptotic pathway, PNC-27 has demonstrated potent tumoricidal activity in preclinical studies without traditional chemotherapy toxicity. This peptide is being explored in solid tumor, hematological malignancy, and oncogene-targeted therapy models. Mechanism of Action: Binds with high affinity to HDM-2, re